The college’s 42-acre campus is located in the community of McPherson, in predominantly rural central Kansas. According to the most recent census figures, McPherson County is home to 29,356 people; 23.3 percent of this population is under 18 years of age while 18.7 percent is 65 or older. Ethnic minorities constitute 4.2 percent of the county’s population.

The present campus, with its 19 major buildings and 42-acre setting, has matured into an institution of which its founders would be proud. To celebrate its 100th anniversary in 1987-88, McPherson College architecturally redesigned its entire campus, a factor that has improved the quality of living and learning at McPherson College. In the spring of 2000 state-of-the-art theatre and fine arts facilities were added to the instructional facilities, and Melhorn Science Hall opened its doors for fall 2001 classes.

In 2016 the college invested $7.4M in its heating and cooling system and also began installing a keyless entry system on its exterior doors that includes security cameras.